Easy-Synthesis of BDA/ABDA Functionalized Hydrophilic Superparamagnetic Iron Oxide Nanoparticles for Magnetic-Hyperthermia Application

Herein, we have reported an easy process for the synthesis of superparamagnetic iron oxide nanoparticles (SPIOs, with a size of ~ 10 nm), where these SPIOs are surface-functionalized with novel pi-electron rich surfactants such as 1,4-benzene dicarboxylic acid (BDA) and 2-amino-1,4-benzene dicarboxylic acid (ABDA). The BDA/ABDA capped SPIOs have demonstrated well crystalline character, excellent colloidal stability, and high saturation magnetization. Moreover, these capped SPIOs have shown good heating ability in magnetic-hyperthermia studies under an alternating magnetic field at a medically suitable frequency, as compared to the previously reported SPIOs based heating-agents. Thus, the as-prepared BDA/ABDA-SPIOs can be used as promising heating agents for magnetic-hyperthermia based biomedical applications.