Preparation And Characterization Of Polyvinyl Alcohol–pectin Cryogels Containing Enrofloxacin And Keratinase As Potential Transdermal Delivery Device

Polyvinyl alcohol (PVA) and polyvinyl alcohol-pectin (PVA-P) cryogels are potential devices for wound healing. These materials have advantages over commercial wound dressings such as: retaining an appropriate level of moisture around wound and gas permeability and antibacterial properties. In a previous work, PVA-P cryogels containingan antibiotic and an enzyme (enrofloxacin and keratinase respectively) have been developed with promising results. In the present work, an exhaustive chemical, morphological and physical characterization of these films was carried out in order to explain the effect of incorporation of pectin into PVA matrix. The results show that the presence of pectin in PVA cryogel increase the size of PVA nanodomains determined by XRD patterns indicating an interaction between both PVA and pectin polymers. PVA nanodomains and crystallinity degree changed when enrofloxacin and keratinase were immobilized into PVA-P cryogels determined by SAXS and DSC analysis. These resu