Carvedilol drug-organo montmorillonite nanocomposites: Preparation, characterization and drug release studies

In this study the Carvedilol drug-organo modified montmorillonite (CV/OMMT) nanocomposites were prepared using different organo modified MMT (Nanomer 1.31PS, Nanomer 1.34TCN, Nanomer 1.44P) through solution intercalation method. The degree of intercalation, microstructure and morphology of the nanocomposites were characterized by FTIR spectroscopy, thermogravimetric analysis and transmission electron microscopic analysis. The purpose of this study is to elaborate the drug loading capacities and drug release behaviours of different organo modified MMT (OMMT) on enhancing their swelling in aqueous medium. The in vitro drug release profiles from the CV/OMMT nanocomposites at pH 1.2 and pH 7.4 were also assessed. Simultaneously, the drug release kinetic parameters for all the CV/OMMT nanocomposites at both gastric and intestinal pH have also been discussed with established mathematical models.