Chemical Processing and Physical-Chemical and Mechanical Characterizations of Poly (L-co-D, L lactic acid)/Polyethylene Glycol Mixtures for Application as a Biomedical Device

The chemical processing of polymeric mixtures is a promising alternative for designing materials with new characteristics for biomedical applications. This work proposed to produce and characterize polymeric mixtures obtained using polyethylene glycol (PEG400 or PEG4000) with poly (L-co-D, L lactic acid)/PLDLA for biomedical use. The mixtures were prepared by the casting method. Characterizations were performed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), mechanical properties (perforation, resilience, elastic modulus, plastic deformation, tensile strength and mucoadhesion) and in vitro biodisintegration studies. The results obtained by FTIR and DSC suggest that the chemical interactions that generate the mixtures between the polymers occurred through hydrogen bonds and/or dipole-dipole interactions. Chemical interactions created compounds that were more hydrophilic and had different rearrangements when using PEG400 or PEG4000 in